I am playing through Prime 2 at the moment and its also amazing. I finally played through Metroid Prime on Primehack at 4k 60 FPS and with a texture pack to make the game look amazing. It was made to specifically optimize Dolphin to run the games using the mouse and keyboard, and included several quality of life upgrades such as being able to adjust the FOV.
Metroid prime trilogy dolphin mouse and keyboard series#
I posted a thread here asking the status of playing the series on Dolphin and Solid clued me in on the specialized fork of Dolphin called Primehack. I have been a long time user of the Dolphin Emulator but due to the first person motion controls and performance issues playing the series on the emulator never really was something that you could do.įast forward to last year. This story was originally published by the Michigan Health Lab Blog on July 3, 2018.For years I had wanted to play the Metroid Prime series but for whatever reason never got around to playing it even though I owned the Trilogy version on the Wii and Wii U. Researchers hope to bring this concept to the clinic in the next few years.ĭisclosure: Wicha holds equity in OncoMed Pharmaceuticals. Researchers are also understanding that the immune system is regulated by metabolism, suggesting the possibility of combining anti-stem cell therapies with immunotherapies. “Rather than just try to use toxic chemicals to kill a cell, we use the metabolism of the cell itself to kill the cancer,” Wicha says. Results are published in Cell Metabolism. They tested this in mice with breast cancer and found they could knock out the stem cells. They used a drug currently used to treat arthritis that’s known to block mitochondria, and they manipulated glucose to block that path. So researchers attacked the metabolism in both ways. In the dormant state, the cells use glucose in the proliferative state, they depend on oxygen. It turns out the cell metabolism controls this change, suggesting a possible way in to attack the stem cells.Ĭells get energy through mitochondria, which depends on oxygen, and through sugar, or glucose. “This tells us we’re going to need multiple stem cell therapies to attack multiple forms of stem cells,” he says. They change form to evade the targeted therapy,” says Wicha, Madeline and Sidney Forbes professor of oncology and director of the Forbes Institute for Cancer Discovery at the Rogel Cancer Center.
A lot of that resistance is from the cancer stem cells. “When we use targeted therapies, they often only work for a certain period of time, and then the cancer becomes resistant. This plasticity is responsible for cancer’s two key characteristics: multiplying and spreading. Now, researchers have found that cancer stem cells exist in more than one state and are very plastic, meaning they can change form, sliding back and forth between a dormant state and a rapidly growing state. Strike it down in one place, and it pops back up in another. Kill the stem cells, and you could master the cancer.īut cancer is like a game of whack-a-mole. Wicha, M.D., and colleagues discovered that a small number of cells within a tumor - the cancer stem cells - were responsible for fueling the growth and spread of cancer. Researchers at the University of Michigan Rogel Cancer Center are unraveling a crucial thread that explains why cancer so often becomes resistant to treatment.
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